Last updated: 2023-10-19

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Knit directory: Methamphetamine_MicroglialRNASequencing_Analysis/

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Luis Tuesta Lab

https://www.tuestalab.org

University of Miami Miller School of Medicine
Rosenstiel Medical Science Building
1600 NW 10th Ave.
Rooms: 7014, 7019
Miami, FL 33136

Our Research

Addiction is a chronic, relapsing disease characterized by compulsive drug-taking and the inability to stop despite negative consequences. Underlying the behavioral progression of the disease are changes in gene expression that are regulated in a cell-type specific fashion. Owing to the rich cell heterogeneity in the brain, understanding how gene expression is regulated throughout the course of addiction in specific cell populations remains both a technical and conceptual challenge for our field.

To this end, our team focuses on understanding the addicted brain by tailoring molecular profiling methods and bioinformatics approaches to ask how transcription is regulated within genetically-defined cell populations in the brain reward system, with special emphasis on dopamine neurons and microglia. Combined with mouse models of drug addiction (IV self-administration), we work to identify genetic targets that can regulate different stages of the disease, and ultimately curb drug-taking and prevent relapse in addicted individuals.

Our Team

Alexander Margetts, B.S.

Ph.D. Candidate
Cancer Graduate Program
University of Miami Miller School of Medicine
Undergrad: University of Miami
Email: avm27@miami.edu

Samara J. Vilca, B.A.

Ph.D. Candidate
Neuroscience Graduate Program
University of Miami Miller School of Medicine
Undergrad: Florida Atlantic University
Email: svilca@miami.edu

Tate A. Pollock, B.S.

Ph.D. Candidate
Neuroscience Graduate Program
University of Miami Miller School of Medicine
Undergrad: University of Alabama Birmingham
Email: tap125@miami.edu

Lauren Bystrom, B.S.

Ph.D. Candidate
Neuroscience Graduate Program
University of Miami Miller School of Medicine
Undergrad: University of Minnesota
Email: llb81@miami.edu

Luis M. Tuesta, Ph.D.

Assistant Professor
Department of Psychiatry and Behavioral Sciences
University of Miami Miller School of Medicine
Postdoc: Harvard Medical School/HHMI
Graduate: The Scripps Research Institute
Undergrad: University of Miami
Email: ltuesta@miami.edu

Funding

Supported By:

K01-DA045294
DP1-DA051858